Now 64, the Back to the Future star continues to embody the determination and humor that made him a household name, though he recently opened up about some deeply personal challenges.

In recent years, Fox has co-written a new memoir, Future Boy, reflecting on the film that launched his career.

He’s also appeared on Apple TV’s Shrinking alongside Harrison Ford and has remained a tireless advocate for Parkinson’s research through the Michael J. Fox Foundation, which has raised more than $2 billion so far. E

Earlier this year, he was honored with the Presidential Medal of Freedom for his contributions to advancing understanding of the disease.